After the albumin-bound toxins leave their blood-side carrier proteins and have passed through the pores of the special membrane, those of the albumin molecules in the middle circulation are taken over and transported away. Through the adsorption column, the loaded albumin is regenerated in the medium cycle and can take over toxins again in the blood filter.
The “single pass” dialysis circuit on the right also allows the elimination of water-soluble substances and the maintenance and adjustment of the acid / base balance and the electrolyte concentration.
Furthermore, as in conventional haemofiltration procedures in intensive care units, the volume balance of the patient can be controlled here.
The principle in detail:
The patient’s blood flows via a catheter into an extracorporeal circuit with a hemodialysis machine containing a special hollow-fiber membrane (see right). The outside of this membrane is lapped by a recirculating human albumin solution and thus purified. Since the “liver toxins” are transported by protein binding, this mechanism causes the driving force for these toxins to pass through the blood membrane. The binding solution is then regenerated directly in a closed circuit (hepatic detoxification) and is itself subjected to dialysis by means of a steamed aqueous solution (renal detoxification). After this regeneration, the membrane can be cleaned again by means of the purified albumin solution. This principle allows the replacement of the detoxifying function of the liver, which, if it is absent in liver failure, is life-threatening.